Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis.

Humphrey MulengaChambrez-Zita ZauchenbergerErick W BunyasiStanley Kimbung MbandiSimon C MendelsohnBenjamin KaginaAdam Penn-NicholsonThomas J ScribaMark Hatherill

Published in: PloS one (2020)

Host blood mRNA signatures hold promise as triage tests for TB. Further optimisation is needed if mRNA signatures are to be used as standalone diagnostic or predictive tests for therapeutic decision-making.

Keyphrases

decision making
genome wide
mycobacterium tuberculosis
emergency department
binding protein
single cell
gene expression
rna seq
machine learning
hiv aids
hepatitis c virus
hiv infected
artificial intelligence
electronic health record
antiretroviral therapy