Pharmacogenetic determinants of thiopurines in an Indian cohort.

Shaik Mohammad NaushadMekala Janaki RamaiahVijay Kumar KutalaTajamul HussainSalman A Alrokayan

Published in: Pharmacological reports : PR (2020)

TPMT variants were less frequent in Indian population, while NUDT15*3 is more frequent compared to European and African/African American populations. NUDT15*3 increases aggregation 'hot spot' and induces unfavourable torsion in the protein. NUDT15*5 and TPMT*3C destabilize the respective proteins. TPMT*3A, TPMT*3B and TPMT*3C are associated with a lower binding affinity towards 6-mercaptopurine.

Keyphrases

african american
copy number
gene expression
small molecule
protein protein
mass spectrometry