Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry.
Emily S LauJenna N McNeillSamantha M PaniaguaElizabeth E LiuJessica K WangIngrid V BassettCaitlin A SelvaggiSteven A LubitzAndrea S FoulkesJennifer E HoPublished in: PloS one (2021)
In a sample of 781 men and women hospitalized with COVID-19 infection, men exhibited more robust inflammatory activation as evidenced by higher initial and peak inflammatory markers, as well as worse clinical outcomes. Better understanding of sex differences in immune responses to COVID-19 infection may shed light on the pathophysiology of COVID-19 infection.