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Intrinsic resistance to ROS1 inhibition in a patient with CD74-ROS1 mediated by AXL overexpression.

Tara L PetersNan ChenLogan C TylerAnh T LeAnastasios DimouRobert C Doebele
Published in: Thoracic cancer (2023)
In summary, we demonstrate that AXL overexpression is a mechanism of intrinsic resistance to ROS1 inhibitors.
Keyphrases
  • cell death
  • dna damage
  • reactive oxygen species
  • tyrosine kinase
  • cell proliferation
  • transcription factor
  • oxidative stress