Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice.

Joanna TorresJianzhong HuAkihiro SekiCaroline EiseleNilendra NairRuiqi HuangLeonid TarassishinBindia JharapJustin Cote-DaigneaultQixing MaoIlaria MognoGraham J BrittonMathieu UzzanChing-Lynn ChenAsher KornbluthJames GeorgePeter LegnaniElana MaserHolly LoudonJoanne StoneMarla DubinskyJeremiah J FaithJose C ClementeSaurabh MehandruJean-Frederic ColombelInga Peter

Published in: Gut (2019)

Aberrant gut microbiota composition persists during pregnancy with IBD and alters the bacterial diversity and abundance in the infant stool. The dysbiotic microbiota triggered abnormal imprinting of the intestinal immune system in GFM.

Keyphrases

ulcerative colitis
high fat diet induced
low birth weight
gestational age
antibiotic resistance genes
preterm infants
insulin resistance
type diabetes
metabolic syndrome
wild type
skeletal muscle
microbial community
wastewater treatment