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Macrophage niche imprinting as a determinant of macrophage identity and function.

Malgorzata KlocMarta HalasaRafik M Ghobrial
Published in: Cellular immunology (2024)
Macrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype, and behavior. The niche, besides physically supporting macrophages, imposes a tissue- and organ-specific identity on the residing and infiltrating monocytes and macrophages. In this review, we give examples of macrophage niches and the modes of communication between macrophages and surrounding cells. We also describe how macrophages, acting against their immune defensive nature, can create a hospitable niche for pathogens and cancer cells.
Keyphrases
  • adipose tissue
  • extracellular matrix
  • induced apoptosis
  • cell cycle arrest
  • transcription factor
  • cell death
  • oxidative stress
  • signaling pathway
  • dna binding