BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
Florian SeltRomain SigaudGintvile ValinciutePhilipp SieversJulia ZamanClara AlcoSimone SchmidHeike PeterzielJessica W TsaiRomain GuihoJuan Pedro Martínez-BarberaStefan PuschJing DengYifan ZhaiCornelis M van TilburgMartin U SchuhmanAhmed E L DamatyPratiti BandopadhayayChristel Herold-MendeAndreas von DeimlingStefan M PfisterJoan MonteroDavid CapperIna OehmeFelix SahmDavid T W JonesOlaf WittTill MildePublished in: Neuro-oncology (2022)
Our data demonstrates that BCL-XL is critical for survival of senescent PA tumor cells and provides proof-of-principle for the use of clinically available BCL-XL-dependent senolytics.