The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.

Ruixue ZhangYing WenJinpeng LiuJiawen HaoYuan PengMiao ZhangYunxiao XieZhaohui YangXuewei YinYongwei ShiHongsheng Bi Dadong Guo

Published in: Journal of translational medicine (2024)

miR-15b-5p/miR-379-3p can regulate the scleral cell cycle and apoptosis through the IGF1R/PTEN/FOXO signaling pathway, thereby promoting scleral remodeling in myopia progression.

Keyphrases

cell cycle
pi k akt
cell cycle arrest
cell proliferation
signaling pathway
oxidative stress
endoplasmic reticulum stress
epithelial mesenchymal transition
induced apoptosis
cell death
optic nerve
transcription factor