Chemiluminescent Probes Based on 1,2-Dioxetane Structures For Bioimaging.
Yaling WangYongning BianXueqian ChenDongdong SuPublished in: Chemistry, an Asian journal (2022)
Chemiluminescent probes based on 1,2-dioxetane scaffold are one of the most sensitive imaging modalities for detecting disease-related biomarkers and can obtain more accurate biological information in cells and in vivo. Due to the elimination of external light excitation, the background autofluorescence problem in fluorescence technology can be effectively avoided, providing ultrahigh sensitivity and signal-to-noise ratio for various applications. In this review, we highlight a comprehensive but concise overview of activatable 1,2-dioxetane-based chemiluminescent probes by reporting significant advances in accurate detection and bioimaging. The design principles and applications for reactive species, enzymes, and other disease-related biomarkers are systematically discussed and summarized. The challenges and potential prospects of chemiluminescent probes are also discussed to further promote the development of new chemiluminescence methods for biological analysis and diagnosis.
Keyphrases
- living cells
- fluorescent probe
- fluorescence imaging
- single molecule
- high resolution
- small molecule
- energy transfer
- photodynamic therapy
- induced apoptosis
- quantum dots
- nucleic acid
- cell cycle arrest
- air pollution
- mass spectrometry
- adverse drug
- loop mediated isothermal amplification
- health information
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- cell death
- genetic diversity