Limited Sampling Strategies Fail to Accurately Predict Mycophenolic Acid Area Under the Curve in Kidney Transplant Recipients and the Impact of Enterohepatic Recirculation.
Moataz Ehab MohamedAbdelrahman SaqrMahmoud Al-KofahiGuillaume OnyeaghalaRory P RemmelChristopher StaleyCasey R DorrLevi TeigenWeihua GuanHenry MaddenJulia MunozDuy VoBryan SanchezRasha El-RifaiWilliam S OettingArthur J MatasAjay K IsraniPamala A JacobsonPublished in: Therapeutic drug monitoring (2024)
The predictive performance of the LSS models varied according to EHR status. Timepoints ≥5 hours postdose in LSS models are essential to capture EHR. Models and strategies that incorporate EHR during development are required to accurately ascertain MPA exposure.