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Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer.

Philipp MetzgerSabrina V KirchleitnerMichael KlugeLars M KoenigChristine HörthCarlotta A RambuscheckDaniel BöhmerJulia AhlfeldSebastian KoboldCaroline C FriedelStefan EndresMax SchnurrPeter Duewell
Published in: Journal for immunotherapy of cancer (2019)
We provide evidence that the treatment with immunostimulatory RNA reprograms the TME of pancreatic cancer by reducing the suppressive activity of MDSC, polarizing myeloid cells into a M1-like state and recruiting DC. We postulate that tumor cell-targeting combination strategies may benefit from RLH-based TME remodeling. In addition, we provide novel insights into the dual role of IFN signaling in MDSC's suppressive function and provide evidence that host-intrinsic IFN signaling may be critical for MDSC to gain suppressive function during tumor development.
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