A Historical Overview of the Role of Benzodiazepines including Clonazepam in the Treatment of Adult Restless Legs Syndrome and Periodic Limb Movements in Sleep.

Arthur S Walters Karen Spruyt Djibril M Ba Xiang Gao

Published in: Tremor and other hyperkinetic movements (New York, N.Y.) (2024)

Benzodiazepines are frequently used as therapy in Restless Legs Syndrome (RLS) and Periodic Limb Movements in Sleep. The order of benefit is Sleep>RLS>PLMS and arousals > PLMS. For clonazepam dosages of 0.5 mg-2.0 mg/day are most frequently employed. Benzodiazepines exert their therapeutic effect through GABA-ergic mechanisms.

Keyphrases

sleep quality
physical activity
case report
depressive symptoms
young adults
combination therapy
cell therapy
replacement therapy