Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases.

A FerrariE FiorinoR LongoS BarillaN MitroG CermenatiM GiudiciD CarusoA MaiU GuerriniE De FabianiMaurizio Crestani

Published in: International journal of obesity (2005) (2016)

This study provides evidence that class I HDAC inhibition stimulated functionality and oxidative potential of adipose tissue, improving glucose tolerance and ameliorating the metabolic profile in diet-induced obese mice.

Keyphrases

adipose tissue
insulin resistance
high fat diet induced
metabolic syndrome
type diabetes
high fat diet
weight loss
dna methylation
weight gain
gene expression
skeletal muscle
physical activity
histone deacetylase
human health
body mass index