Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients.
Akua Afriyie KarikariWasco WruckJames AdjayePublished in: Malaria journal (2021)
Results from this study reveal that P. falciparum-mediated inflammatory and cellular stress mechanisms may impair brain function in MM, NCM and CM. However, the neurological deficits predominantly reported in CM cases could be attributed to the down-regulation of various genes involved in cellular function through transcriptional repression, axonal dysfunction, dysregulation of signalling pathways and neurodegeneration. It is anticipated that the data from this study, might form the basis for future hypothesis-driven malaria research.
Keyphrases
- plasmodium falciparum
- dna damage response
- end stage renal disease
- gene expression
- chronic kidney disease
- single cell
- traumatic brain injury
- newly diagnosed
- genome wide
- peritoneal dialysis
- dna methylation
- prognostic factors
- current status
- rna seq
- multiple sclerosis
- machine learning
- brain injury
- dna damage
- heat shock
- heat shock protein