Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality: a prospective study.
Amra JujićNaeimeh Atabaki-PasdarPeter M NilssonPeter AlmgrenLiisa HakasteTiinamaija TuomiLisa M BerglundPaul W FranksJens J HolstRashmi B PrasadSigne S TorekovSusana RavassaJavier DíezMargaretha PerssonOlle MelanderMaria F GomezLeif GroopEmma AhlqvistMartin MagnussonPublished in: Diabetologia (2020)
In two prospective, community-based studies, elevated levels of GIP were associated with greater risk of all-cause and cardiovascular mortality within 5-9 years of follow-up, whereas GLP-1 levels were not associated with excess risk. Further studies are warranted to determine the cardiovascular effects of GIP per se.