Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil.
Evelina ParisiAna M GarciaDomenico MarsonPaola PosoccoSilvia MarchesanPublished in: Gels (Basel, Switzerland) (2019)
In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations.
Keyphrases
- molecular dynamics simulations
- high performance liquid chromatography
- drug delivery
- electron microscopy
- simultaneous determination
- tandem mass spectrometry
- solid phase extraction
- mass spectrometry
- energy transfer
- molecular docking
- cancer therapy
- ms ms
- high frequency
- hyaluronic acid
- tissue engineering
- drug release
- liquid chromatography
- single molecule
- wound healing
- molecular dynamics
- emergency department
- electron transfer
- electronic health record
- quantum dots