Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia.
Robert ChiesaChristos GeorgiadisFarhatullah SyedHong ZhanAnnie EtukSoragia Athina GkaziRoland PreeceGiorgio OttavianoToni BraybrookJan ChuAgnieszka KubatStuart AdamsRebecca ThomasKimberly GilmourDavid O'ConnorAjay VoraWaseem Qasimnull nullPublished in: The New England journal of medicine (2023)
The interim results of this phase 1 study support further investigation of base-edited T cells for patients with relapsed leukemia and indicate the anticipated risks of immunotherapy-related complications. (Funded by the Medical Research Council and others; ISRCTN number, ISRCTN15323014.).