A "Four Core Genotypes" rat model to distinguish mechanisms underlying sex-biased phenotypes and diseases.

Arthur P ArnoldXuqi ChenMichael N GrzybowskiJanelle M RyanDale R SengelaubTara MohanroyV Andree FurlanWilliam GrishamLynn MalloyAkiko TakizawaCarrie B WieseLaurent VergnesHelen SkaletskyDavid C PageKaren ReueVincent R HarleyMelinda R DwinellAron M Geurts

Published in: bioRxiv : the preprint server for biology (2023)

The results establish a powerful new model to discriminate sex chromosome and gonadal hormone effects that cause sexual differences in rat physiology and disease.

Keyphrases

mental health
oxidative stress
copy number