Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
Erik LadomerskyLijie ZhaiKristen L LauingApril BellJiahui XuMasha KocherginskyBin ZhangJennifer D WuJoseph R PodojilLeonidas C PlataniasAaron Y MochizukiRobert M PrinsPriya KumthekarJeffrey J RaizerKaran S DixitRimas V LukasCraig HorbinskiMin WeiChangyou ZhouGraham P PawelecJudith CampisiUrsula GrohmannGeorge C PrendergastDavid H MunnDerek A WainwrightPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Immunosuppression increases in the brain during advanced age and inhibits antiglioma immunity in older adults. Going forward, it will be important to fully understand the factors and mechanisms in the elderly brain that contribute to the decreased survival of older patients with GBM during treatment with ICB.