Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.

Martin SjöströmLinda HartmanGabriella HonethDorthe GrabauPer MalmströmCecilia HegardtMårten FernöEmma Niméus

Published in: Journal of clinical pathology (2015)

ALDH1A1 is associated with DDFS and clinicopathological variables, both in cancer cells and stroma, but is highly cut-off dependent. Only the strongly ALDH1A1-stained cells show a more aggressive phenotype typical for CSCs.

Keyphrases

stem cells
cell cycle arrest
cell proliferation
bone marrow
pi k akt