Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals its novel function in promoting muscle atrophy.

Jianjun JinMengmeng DuJian WangYubo GuoJiali ZhangHao ZuoYunqing HouShanshan WangWei LvWei BaiJin WangXizhen ZhanYaxin PengQian TongJin ChaiZaiyan XuBo Zuo

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Our results identify SYISL as a conserved lncRNA that modulates myogenesis in mice, pigs, and humans. We also demonstrated its previously unknown ability to promote muscle atrophy.

Keyphrases

skeletal muscle
long non coding rna
long noncoding rna
transcription factor
high fat diet induced
insulin resistance
metabolic syndrome
adipose tissue