Activation of Frizzled-7 attenuates blood-brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice.

Wei HeQin LuPrativa SherchanLei HuangXin HuJohn H ZhangHaibin DaiJi-Ping Tang

Published in: Fluids and barriers of the CNS (2021)

Frizzled-7 activation potentially attenuated BBB permeability and improved neurological deficits after ICH through Dvl/β-Catenin/WISP1 pathway. Frizzled-7 may be a potential target for the development of ICH therapeutic drugs.

Keyphrases

blood brain barrier
epithelial mesenchymal transition
cerebral ischemia
signaling pathway
cell proliferation
brain injury
high fat diet induced
endothelial cells
metabolic syndrome
oxidative stress
induced apoptosis
human health
risk assessment
insulin resistance
skeletal muscle