Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas.

Elizabeth G Gibson Olivia CampagneNicholas S SelvoAmar GajjarClinton F Stewart

Published in: Cancer chemotherapy and pharmacology (2021)

A potential pharmacokinetic interaction was observed between crizotinib and dasatinib in children with HGG and DIPG. Further, crizotinib exposure was significantly higher in overweight/obese patients, who may require a dosing adjustment.

Keyphrases

high grade
low grade
advanced non small cell lung cancer
young adults
weight loss
multiple sclerosis
type diabetes
physical activity
bariatric surgery
epidermal growth factor receptor
obese patients
weight gain
climate change