Effects of Coronary Artery Disease-Associated Variants on Vascular Smooth Muscle Cells.
Charles Ugochukwu SolomonDavid G McVeyCatherine AndreadiPeng GongLenka TurnerPaulina J StanczykSonja KhemiriJulie C ChamberlainWei YangThomas R WebbChristopher P NelsonNilesh J SamaniShu YePublished in: Circulation (2022)
This comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior. Several candidate causal genes identified are likely to be druggable and thus represent potential therapeutic targets.
Keyphrases
- vascular smooth muscle cells
- coronary artery disease
- gene expression
- angiotensin ii
- genome wide
- dna methylation
- percutaneous coronary intervention
- coronary artery bypass grafting
- copy number
- cardiovascular events
- heart failure
- type diabetes
- climate change
- acute coronary syndrome
- bioinformatics analysis
- aortic valve
- genome wide association