Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation.

Joshua RheinKathy H HullsiekEmily E EvansLillian TugumeEdwin NuwagiraKenneth SsebambuliddeReuben KiggunduEdward MpozaAbdu K MusubireAnanta S BangdiwalaNathan C BahrDarlisha A WilliamsMahsa AbassiConrad MuzooraDavid B MeyaDavid R Boulwarenull null

Published in: Open forum infectious diseases (2018)

Cryptococcosis after ART initiation is common in Africa. Patients initiating ART who unmask cryptococcal meningitis are at a high risk of death. Immune recovery in the setting of central nervous system infection is detrimental, and management of this population requires further study. Implementing pre-ART cryptococcal antigen screening is urgently needed to prevent cryptococcal meningitis after ART initiation.

Keyphrases

hiv infected
cerebrospinal fluid
antiretroviral therapy
end stage renal disease
ejection fraction
chronic kidney disease
type diabetes
peritoneal dialysis
adipose tissue
metabolic syndrome
patient reported outcomes
glycemic control