LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
Huan YueKaifeng WuKanglin LiuLuxia GouAilong HuangHua TangPublished in: Cellular oncology (Dordrecht) (2022)
Our data suggest that Linc02154 may serve as a valuable biomarker of HCC and as a potential therapeutic target.
Keyphrases
- signaling pathway
- long non coding rna
- long noncoding rna
- cell proliferation
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- dna methylation
- electronic health record
- transcription factor
- gene expression
- big data
- human health
- oxidative stress
- risk assessment
- data analysis
- deep learning
- machine learning
- endoplasmic reticulum stress