Aortic valve endocarditis due to Bartonella clarridgeiae in a dog in Brazil.
Marcos Rogério AndréRaphaela Arantes Marques CanolaJaislane Bastos BrazIsabella Fernanda Spinelli PerossiAna Claudia CalchiPriscila IkedaRosangela Zacarias MachadoRosemeri de Oliveira VasconcelosAparecido Antonio CamachoPublished in: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria (2020)
We report the first documented case of endocarditis associated with Bartonella clarridgeiae in a dog in Latin America. Infective vegetative valvular aortic endocarditis was diagnosed in a 10-year-old male mixed breed dog. The dog presented grade V/VI systolic and diastolic murmur, hyperthermia, and progressive weight loss. Cardiomegaly and presence of diffuse alveolar pattern in the lung fields were observed in the thorax radiography evaluation. Irregular and hyperechogenic structures adhered to the aortic leaflets, causing obstruction of the left ventricular outflow tract and severe aortic insufficiency, were observed in the echocardiography evaluation. A vegetative, whitish, hardened structure measuring 1.0 cm in diameter was observed in aortic semilunar valve at necropsy. Based on a combination of pre-enrichment insect-based medium liquid culture, quantitative real-time and conventional PCR assays based on nuoG and gltA genes, respectively, followed by sequencing and phylogenetic inferences, B. clarridgeiae DNA was detected in the patient's aortic valve lesions. Clinical, echocardiographic, anatomopathologic and molecular features supported the diagnosis of severe aortic vegetative endocarditis possibly caused by B. clarridgeiae in a dog in Brazil.
Keyphrases
- aortic valve
- left ventricular
- aortic stenosis
- transcatheter aortic valve replacement
- aortic valve replacement
- transcatheter aortic valve implantation
- hypertrophic cardiomyopathy
- weight loss
- heart failure
- blood pressure
- acute myocardial infarction
- cardiac resynchronization therapy
- multiple sclerosis
- left atrial
- mitral valve
- bariatric surgery
- early onset
- high resolution
- pulmonary hypertension
- computed tomography
- single molecule
- case report
- transcription factor
- body mass index
- gene expression
- coronary artery disease
- mass spectrometry
- cone beam computed tomography
- aedes aegypti