Dual Angiotensin Receptor and Neprilysin Inhibitor Ameliorates Portal Hypertension in Portal Hypertensive Rats.

Shao-Jung HsuHui-Chun HuangChiao-Lin ChuangChing-Chih ChangMing-Chih HouFa-Yauh LeeShou-Dong Lee

Published in: Pharmaceutics (2020)

LCZ696 and valsartan reduced mean arterial pressure through peripheral vasodilation. Furthermore, LCZ696 significantly reduced portal pressure in PVL rats via hepatic ET-1 downregulation.

Keyphrases

blood pressure
signaling pathway
angiotensin ii
mouse model
angiotensin converting enzyme
binding protein
arterial hypertension