Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication.

Elizabeth R VanderwallKaitlyn A BarrowLucille M RichDavid F ReadCole TrapnellOghenemega OkolokoSteven F ZieglerTeal S HallstrandMaria P WhiteJason S Debley

Published in: bioRxiv : the preprint server for biology (2021)

In addition to marked between-donor heterogeneity in IFN responses and viral replication, SARS-CoV-2 elicits a less robust IFN response in primary AEC cultures than does rhinovirus, and heterologous rhinovirus infection, or treatment with recombinant IFN-β1 or IFN-λ2, markedly reduces SARS-CoV-2 replication.

Keyphrases

sars cov
dendritic cells
respiratory syndrome coronavirus
immune response
signaling pathway
saccharomyces cerevisiae
single cell
combination therapy
coronavirus disease
respiratory tract