Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.

Nicholas R PerkonsOmar JohnsonGabrielle PillaEnri ProfkaMichael MercadanteDaniel Ackerman Terence P F Gade

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These findings demonstrate that DNP-MRSI of LDH activity using hyperpolarized [1-13C]-pyruvate is a theranostic strategy for hepatocellular carcinoma, enabling quantification of intratumoral LDHi pharmacodynamics and therapeutic efficacy prediction. This work lays the foundation for a novel theranostic platform wherein functional genetic screening informs imaging probe selection to quantify therapeutic efficacy on a cancer-by-cancer basis.

Keyphrases

papillary thyroid
squamous cell
photodynamic therapy
fluorescence imaging
genome wide
high resolution
gene expression
high throughput
mass spectrometry
quantum dots