Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice.

Markus Wöhr Wendy M Fong Justyna A Janas Moritz Mall Christian Thome Madhuri Vangipuram Lingjun Meng Thomas C Südhof Marius Wernig

Published in: Molecular autism (2022)

Behavioral alterations in Myt1l haploinsufficient mice recapitulate several clinical phenotypes observed in humans carrying heterozygous MYT1L mutations and thus serve as an informative model of the human MYT1L syndrome.

Keyphrases

high fat diet induced
insulin resistance
endothelial cells
metabolic syndrome
type diabetes
weight loss
early onset
induced pluripotent stem cells