Tollip interaction with STAT3: a novel mechanism to regulate human airway epithelial responses to type 2 cytokines.
Niccolette SchaunamanKris Genelyn DimasuayMonica KraftHong Wei ChuPublished in: Respiratory research (2022)
Our results, for the first time, suggest that Tollip inhibits excessive eotaxin-3 induction by IL-13, in part through the interaction and inhibition of STAT3. These findings lend evidence to the potential of a STAT3 inhibitor as a therapeutic target, especially for type 2 inflammation-high asthmatics with Tollip deficiency.