Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury.
Chaoyan HanXin ZhaoXiao-Kui HuoZhenlong YuChao WangLei FengJing-Nan CuiXiang-Ge TianXiao-Chi MaPublished in: Chemical communications (Cambridge, England) (2023)
An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging. In addition, ERBM was applied to illustrate the regulation characteristics of CES1 under ER stress and acute liver injury models at the cell and animal level.
Keyphrases
- fluorescent probe
- liver injury
- drug induced
- living cells
- endoplasmic reticulum
- endoplasmic reticulum stress
- single cell
- cell therapy
- induced apoptosis
- adverse drug
- high resolution
- liver failure
- cancer therapy
- photodynamic therapy
- mesenchymal stem cells
- single molecule
- drug delivery
- signaling pathway
- hepatitis b virus
- label free
- loop mediated isothermal amplification
- fluorescence imaging
- acute respiratory distress syndrome