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Progressive and Parallel Decline of Humoral and T-Cell Immunity in Convalescent Healthcare Workers with Asymptomatic or Mild-to-Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

José Luis CasadoPilar VizcarraHector VelascoJohannes HammerleAmaranta McGeeMarina Fernandez-EscribanoAlejandro Vallejo
Published in: The Journal of infectious diseases (2021)
We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.
Keyphrases
  • immune response
  • respiratory syndrome coronavirus
  • coronavirus disease
  • dendritic cells
  • toll like receptor
  • sars cov
  • multiple sclerosis
  • electronic health record
  • big data
  • deep learning
  • inflammatory response