Selective N7 Alkylation of 7-Azaindazoles.
Zhiyu LeiJianming BaoChen ChengWensheng YuBin HuWeichen JinSalman JabriSong YangLianyun ZhaoChristopher J SinzJoseph L DuffyPublished in: The Journal of organic chemistry (2020)
A general and mild procedure for alkylation of 7-azaindazoles at the N7 position using alkyl halides in butanone is reported, which requires no additives such as acids or bases. The scope of the reaction regarding substituents on 7-azaindazoles and the alkyl electrophiles is presented.