Pathophysiology and clinical relevance of atrial myopathy.
Michiel R L TubeeckxGilles W De KeulenaerHein HeidbuchelVincent F M SegersPublished in: Basic research in cardiology (2024)
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy. In this review, we will discuss the pathophysiology of atrial myopathy, as well as diagnostic and therapeutic strategies.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- angiotensin ii
- late onset
- oxidative stress
- oral anticoagulants
- left atrial appendage
- heart failure
- direct oral anticoagulants
- muscular dystrophy
- percutaneous coronary intervention
- coronary artery disease
- vascular smooth muscle cells
- endoplasmic reticulum stress
- skeletal muscle
- heart rate
- venous thromboembolism
- diabetic rats