Plasma Biomarkers of Neuropathogenesis in Hospitalized Patients With COVID-19 and Those With Postacute Sequelae of SARS-CoV-2 Infection.
Barbara A HansonLavanya VisvabharathySareen T AliAnthony K KangTulsi R PatelJeffrey R ClarkPatrick H LimZachary S OrbanSoyoon S HwangDawn MattoonAyush BatraEric M LiottaIgor J KoralnikPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
pNfL, pGFAP, and pN Ag measurements indicate neuronal dysfunction and systemic involvement in hospitalized COVID-19 patients with encephalopathy. Detection of SARS-CoV-2 N Ag in blood 3 weeks after symptoms onset in a nonhospitalized patient suggests that prolonged antigenic stimulation, or possibly latent infection, may occur. Anxiety was associated with evidence of astroglial activation in patients with neuro-PASC. These data shed new light on SARS-Cov-2 neuropathogenesis and demonstrate the value of plasma biomarkers across the COVID-19 disease spectrum.
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