Carbenoxolone and 18β-glycyrrhetinic acid inhibit inositol 1,4,5-trisphosphate-mediated endothelial cell calcium signalling and depolarise mitochondria.

Charlotte Buckley Xun Zhang Calum Wilson John G McCarron

Published in: British journal of pharmacology (2021)

CBX and 18βGA inhibit IP3 -mediated Ca2+ release and depolarise the mitochondrial membrane potential. These results suggest that CBX and 18βGA may block cell-cell communication by acting at sites that are unrelated to gap junctions.

Keyphrases

pet ct
single cell
cell therapy
endothelial cells
oxidative stress
cell death
stem cells
single molecule
endoplasmic reticulum
high glucose
human health