Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway.

Yiming ChenHuiyi YangZhaojie WangRongrong ZhuLiming ChengQian Cheng

Published in: Stem cell research & therapy (2023)

Taken together, LIPUS stimulation could realize articular cartilage regeneration based on hUC-MSC transplantation due to the inhibition of the TNF signaling pathway, which is of clinical value for the relief of osteoarthritis.

Keyphrases

signaling pathway
rheumatoid arthritis
stem cells
pi k akt
cell therapy
mesenchymal stem cells
epithelial mesenchymal transition
induced apoptosis
magnetic resonance imaging
wound healing
knee osteoarthritis
computed tomography
ultrasound guided
cell proliferation
contrast enhanced ultrasound