Mesenchymal stem cells-derived exosomes alleviate liver fibrosis by targeting Hedgehog/SMO signaling.

Ruobin ZongYan ZhengYufei YanWenao SunLiangyi KongYating HuangYujie LiuChaochen JiangJie PingChangyong Li

Published in: Hepatology international (2024)

Our findings suggest that UC-MSCs-Exo exert therapeutic effects on liver fibrosis, at least in part, through inhibiting the Hedgehog/SMO signaling pathway.

Keyphrases

liver fibrosis
mesenchymal stem cells
signaling pathway
umbilical cord
bone marrow
pi k akt
cell therapy
epithelial mesenchymal transition
induced apoptosis
stem cells
oxidative stress
endoplasmic reticulum stress