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Cp*Rh(III)-Catalyzed Mild Addition of C(sp3)-H Bonds to α,β-Unsaturated Aldehydes and Ketones.

Bingxian LiuPanjie HuXukai ZhouDachang BaiJunbiao ChangXingwei Li
Published in: Organic letters (2017)
A Rh(III)-catalyzed addition of benzylic C(sp3)-H bond to α,β-unsaturated ketones/aldehydes has been realized, leading to efficient synthesis of γ-aryl ketones/aldehydes. This atom-economic reaction proceeded under mild and redox-neutral conditions with a broad substrate scope. Besides benzylic C-H, allylic C-H bonds are also applicable when assisted by O-methyl ketoxime directing groups.
Keyphrases
  • electron transfer
  • room temperature
  • transition metal
  • molecular dynamics