Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations.
Denise R NebgenSusan M DomchekJoanne KotsopoulosJoanne A de HulluEmma J CrosbieVincent Singh ParamanandamMonique Brood van ZantenBarbara M NorquistTheresa GuiseSerge RozenbergAllison W KurianHolly J PedersonNesé YukselRachel Michaelson-CohenSharon L BoberAgnaldo Lopes da Silva FilhoNora JohansenF GuidozziDafydd Gareth EvansUsha MenonSheryl A KingsbergC Bethan PowellGiovanni GrandiClaudia MarchettiMichelle JacobsonDonal J BrennanMartha HickeyPublished in: BJOG : an international journal of obstetrics and gynaecology (2023)
Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.
Keyphrases
- healthcare
- breast cancer risk
- polycystic ovary syndrome
- palliative care
- cardiovascular disease
- clinical practice
- mental health
- public health
- quality improvement
- pain management
- affordable care act
- sleep quality
- health information
- patients undergoing
- postmenopausal women
- physical activity
- metabolic syndrome
- coronary artery disease
- bone mineral density
- oxidative stress
- health insurance
- body composition
- pregnancy outcomes
- pregnant women
- climate change
- depressive symptoms
- soft tissue
- men who have sex with men
- chronic pain
- human immunodeficiency virus
- bone loss