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Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells.

Hsin-Yu HoMu-Kuan ChenChia-Chieh LinYu-Sheng LoYi-Ching ChuangMing-Ju Hsieh
Published in: Expert opinion on therapeutic targets (2024)
Our results revealed the antitumor effect of arenobufagin in vitro and in vivo. Arenobufagin may have clinical utility in treating NPC due to its suppression of claspin and inhibition of the JNK pathway.
Keyphrases
  • cell cycle
  • cell proliferation
  • signaling pathway
  • cell death
  • induced apoptosis
  • transcription factor
  • single cell
  • oxidative stress