Inhibition of microRNA-129-2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1.

Guan-Yu WangZhi-Lin LuanNing-Wei CheDe-Bin YanXiao-Wan SunCong ZhangJian Yin

Published in: Brain and behavior (2021)

The results suggested GABRA1 as a target of miR-129-2-3p in rat primary hippocampal neurons and a rat kainic acid (KA) seizure model. Silencing of miR-129-2-3p exerted a seizure-suppressing effect in rats. MiR-129-2-3p/GABRA1 pathway may represent a potential target for the prevention and treatment of refractory epilepsy.

Keyphrases

temporal lobe epilepsy
oxidative stress
spinal cord
signaling pathway
human health
combination therapy
spinal cord injury
blood brain barrier
climate change
subarachnoid hemorrhage