Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization.
Tomasz Kamil UrbanowiczAnna Olasińska-WiśniewskaMichał MichalakBartłomiej PerekAhmed Al-ImamMichał RodzkiAnna WitkowskaEwa Straburzyńska-MigajMichał BociańskiMarcin MisterskiMaciej LesiakMarek JemielityPublished in: PloS one (2022)
Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59-64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17-17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001).
Keyphrases
- coronary artery bypass
- coronary artery bypass grafting
- percutaneous coronary intervention
- coronary artery disease
- inflammatory response
- cardiovascular events
- oxidative stress
- acute coronary syndrome
- end stage renal disease
- minimally invasive
- patients undergoing
- type diabetes
- chronic kidney disease
- lipopolysaccharide induced
- peritoneal dialysis
- left ventricular
- single cell
- prognostic factors