Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma.

Bo ZhangHui PengMi ZhouLei BaoChenliang WangFeng CaiHongxia Zhang Jennifer E WangYanling NiuYan ChenYijie WangKimmo J HatanpaaJohn A CoplandRalph J DeBerardinisYingfei Wang Maowu Luo

Published in: Cancer research (2022)

Metabolic synthetic lethal screening in IDHWT glioblastoma defines a vulnerability to ΑΚG following BCAT1 loss, uncovering a therapeutic strategy to improve glioblastoma treatment. See related commentary by Meurs and Nagrath, p. 2354.

Keyphrases

climate change
cancer therapy
drug delivery
combination therapy