Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease.

SpiroAnthony StathasVictor E AlvarezWeiming XiaRaymond NicksGaoyuan MengSarah DaleyMorgan PothastArsal ShahHunter KelleyCamille EsnaultRobert McCormackErin DixonLucas FishbeinJonathan D CherryBertrand R HuberYorghos TripodisMichael L AloscoJesse MezAnn C McKeeThor D Stein

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)

In frontal cortex, p-tau202 is the most upregulated p-tau species in CTE, while p-tau396 is most increased in AD. p-tau202 and p-tau396 measurements may aid in developing biomarkers for disease.

Keyphrases

cerebrospinal fluid
spinal cord injury
protein kinase
functional connectivity
cognitive decline
working memory
drug induced