Brain volumetric deficits in MAPT mutation carriers: a multisite study.
Stephanie A ChuTaru M FlaganAdam M StaffaroniLize C JiskootJersey DengSalvatore SpinaLiwen ZhangVirginia E SturmJennifer S YokoyamaWilliam W SeeleyJanne M PapmaDan H GeschwindHoward J RosenBradley F BoeveAdam L BoxerHilary W HeuerLeah K ForsbergDanielle E BrushaberMurray GrossmanGiovanni CoppolaBradford C DickersonYvette M BordelonKelley FaberHoward H FeldmanJulie A FieldsJamie C FongTatiana ForoudRalitza H GavrilovaNupur GhoshalNeill R Graff-RadfordGing-Yuek Robin HsiungEdward D HueyDavid J IrwinKejal KantarciDaniel I KauferAnna M KarydasDavid S KnopmanJohn KornakJoel H KramerWalter A KukullMaria I LapidIrene LitvanIan R A MackenzieMario F MendezBruce L MillerChiadi U OnyikeAlexander Y PantelyatRosa RademakersEliana Marisa RamosErik D RobersonMaria Carmela TartagliaNadine A TattonArthur W TogaAshley VetorSandra WeintraubBonnie WongZbigniew K Wszoleknull nullJohn C Van SwietenSuzee E LeePublished in: Annals of clinical and translational neurology (2020)
A subset of presymptomatic MAPT mutation carriers showed low volumes in mesial temporal lobe, the region ubiquitously atrophied in all symptomatic carriers. With each decade of age, an increasing percentage of presymptomatic carriers showed low mesial temporal volume, suggestive of early neurodegeneration.