Downregulation of Insulin-Like Growth Factor-1 Receptor Mediates Chondrocyte Death and Matrix Degradation in Kashin-Beck Disease.

Meng ZhangWenjun WangHui WangYinan LiuZhengzheng LiChengfen YiYawen ShiTianyou MaJinghong Chen

Published in: Cartilage (2021)

Downregulation of IGF-1R was associated with KBD cartilage destruction. Therefore, inhibition of IGF-1R may mediate chondrocyte death and extracellular matrix degeneration related to the pathological progression of KBD.

Keyphrases

extracellular matrix
growth hormone
signaling pathway
cell proliferation
binding protein
pi k akt