Macrophages can secrete exosomes containing miR-223 and promote apoptosis by targeting the IGF-1R/Akt/mTOR signaling pathway in A549 cells and mouse models, suggesting that miR-223 is a potential target for treating COVID-19 induced ARDS.
Keyphrases
- cell proliferation
- pi k akt
- cell cycle arrest
- signaling pathway
- long non coding rna
- induced apoptosis
- long noncoding rna
- acute respiratory distress syndrome
- sars cov
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress
- oxidative stress
- coronavirus disease
- mouse model
- mesenchymal stem cells
- stem cells
- cell death
- high glucose
- diabetic rats
- cell therapy
- binding protein
- bone marrow
- drug induced
- growth hormone
- climate change